Liver Diseases and Adverse Reactions Induced by Medicinal Herbs and Herb-Drug Interactions

VIEWS - 81 (Abstract) 30 (PDF)
Mohammad Khalid Parvez, Naghma Anjum

Abstract


Integrative medicine encompasses several modalities of complementary and alternative medicine, of which the most relevant is the herbal medicine. Herbal formulations contain multiple pharmacologically active phytochemicals with isolated active compounds usually can achieve better therapeutic performance. In general, herbal medicines are believed to be more effective and safer than prescription drugs. Prescription drugs are approved and licensed only after well regulated clinical trials have been carried out, but a majority of marketed herbal products remain non-regulated without evidence of efficacy and safety. In this article, we review the potential risk of liver diseases or other organ toxicity related to herbs or the combined use of herb and drug. This article also discusses certain medicinal herbs as well as hepatotoxicy and adverse reactions induced by herb-drug interactions in liver disease patients.


Keywords


Herbal toxicity, Liver diseases, Adverse drug reaction

Full Text:

Download PDF

References


Kennedy J, 2005, Herb and Supplement Use in the US Adult Population. Clin Ther, 27(11):1847–58. DOI: 10.1016/j. clinthera.2005.11.004

Song PP, Gao JJ, Kokudo N, et al., 2011. Standardization of Traditional Chinese Medicine and Evaluation of Evidence from its Clinical Practice. Drug Discov Ther, 5(6):261–5. DOI: 10.5582/ddt.2011.v5.6.261

Hudson A, Lopez E, Almalki AJ, et al., 2018. A Review of the Toxicity of Compounds Found in Herbal Dietary Supplements. Planta Med, 84:613–26. DOI: 10.1055/a 0605-3786

Charen E, Harbord N, 2020. Toxicity of Herbs, Vitamins, and Supplements. Adv Chronic Kidney Dis, 27:67–71. DOI: 10.1053/j.ackd.2019.08.003

Al-Dosari MS, Parvez MK, 2016. Genetic Polymorphisms of Drug Eliminating Enzymes and Transporters. Biomed Gen Genom, 1:44–50. DOI: 10.15761/BGG.1000109

Chen XW, Sneed KB, Pan SY, et al., 2012. Herb Drug Interactions and Mechanistic and Clinical Considerations. Curr Drug Metab, 13:640–51. DOI: 10.2174/1389200211209050640

Bunchorntavakul C, Reddy KR, 2013, Review article: Herbal and dietary supplement hepatotoxicity. Aliment Pharmacol Ther, 37:3–17. DOI: 10.1111/apt.12109

Teschke R, Wolff A, Frenzel C, et al., 2014, Drug and Herb Induced Liver Injury: Council for International Organizations of Medical Sciences scale for Causality Assessment. World J Hepatol, 6:17–32. DOI: 10.4254/wjh. v6.i1.17

Kim TY, Kim D, 2013, Acute-on-chronic Liver Failure. Clin Mol Hepatol, 19:349–59. DOI: 10.3350/cmh.2013.19.4.349

Gunawan B, Kaplowitz N, 2004, Clinical Perspectives on Xenobiotic Induced Hepatoxicity. Drug Metab Rev, 36:301–12. DOI: 10.1081/dmr-120034148

Pittler MH, Ernst E, 2003, Systematic Review: Hepatotoxic Events Associated with Herbal Medicinal Products. Aliment Pharmacol Ther, 18:451–71. DOI: 10.1046/j.1365- 2036.2003.01689.x

Schiano TD, 2003, Hepatotoxicity and Complementary and Alternative Medicines. Clin Liver Dis, 7(2):453–73. DOI: 10.1016/s1089-3261(03)00030-8

Stedman C, 2002, Herbal Hepatotoxicity. Semin Liver Dis, 22(2): 195–206. DOI: 10.1055/s-2002-30104

Teschke R, Bahre R, 2009. Severe Hepatotoxicity by Indian Ayurvedic Herbal Products: A Structured Causality Assessment. Ann Hepatol, 8(3):258–66.

Jorge OA, Jorge AD, 2005. Hepatotoxicity Associated with the Ingestion of Centella asiatica. Rev Esp Enferm Dig, 97:115–24. DOI: 10.4321/s1130-01082005000200006

Fleig WW, Morgan MY, Holzer MA, 1997. European Multicenter Study Group. The ayurvedic drug Liv.52 in patients with alcoholic cirrhosis. Results of a prospective, randomized, double-blind, placebo-controlled clinical trial. J Hepatol, 126:127.

Izzo AA, Ernst E, 2001. Interactions between Herbal Medicines and Prescribed Drugs: A Systematic Review. Drugs, 61:2163–75. DOI: 10.2165/00003495-200161150- 00002

Woo CS, Lau JS, El-Nezami H, 2012, Herbal Medicine: Toxicity and Recent Trends in Assessing their Potential Toxic Effects. In: Advances in Botanical Research, Cambridge, Massachusetts: Academic Press, pp. 365–84.

Modi AA, Wright EC, Leonard BS, 2007. Complementary and Alternative Medicine for the Treatment of Hepatitis B and C: A Review. Antiviral Ther, 12(3):285–95.

Parvez MK, Al-Dosari MS, Arbab AH, 2021, An update on natural or herbal drugs against hepatitis B virus. In: Hepatitis B: Diagnosis, Prevention and Treatment. New York: Nova Science Publishers, Inc.

Yuen MF, Tam S, Fung J, Wong DK, Wong BC, Lai CL, 2006. Traditional Chinese Medicine Causing Hepatotoxicity in Patients with Chronic Hepatitis B Infection: A 1-year Prospective Study. Aliment Pharmacol Ther, 24(8):1179–86. DOI: 10.1111/j.1365-2036.2006.03111.x

Lee CH, Wang JD, Chen PC, 2011. Risk of Liver Injury Associated with Chinese Herbal Products Containing Radix Bupleuri in 639,779 Patients with Hepatitis B Virus Infection. PLoS One, 6(1):e16064. DOI: 10.1371/journal. pone.0016064

Estes JD, Stolpman D, Olyaei A, et al., 2003. High Prevalence of Potentially Hepatotoxic Herbal Supplement Use in Patients with Fulminant Hepatic Failure. Arch Surg, 138(8):852–8. DOI: 10.1001/archsurg.138.8.852

Choi HA, Kim MR, Park KA, et al., 2012. Interaction of over-the-Counter Drugs with Curcumin: Influence on Stability and Bioactivities in Intestinal Cells. J Agric Food Chem, 60(42):10578–84. DOI: 10.1021/jf303534e

Choi JG, Eom SM, Kim J, et al., 2016. A comprehensive review of recent studies on herb-drug interaction: A focus on pharmacodynamic interaction. J Altern Complement Med, 22:262–79. DOI: 10.1089/acm.2015.0235

Reeta KH, Mehla J, Pahuja M, et al., 2011. Pharmacokinetic and Pharmacodynamic Interactions of Valproate, Phenytoin, Phenobarbitone and Carbamazepine with Curcumin in Experimental Models of Epilepsy in Rats. Pharmacol Biochem Behav, 99:399–407. DOI: 10.1016/j. pbb.2011.05.011

Zhou S, Gao Y, Jiang W, et al., 2003, Interactions of Herbs with Cytochrome P450. Drug Metab Rev, 35:35–98. DOI: 10.1081/dmr-120018248

Food and Drug Administration, 2006, Guidance for Industry on Complementary and Alternative Medicine Products and Their Regulation by the Food and Drug Administration. Draft Guidance, pp. 1–17.

Aydιn A, Aktay G, Yesilada E, 2016, A Guidance Manual for the Toxicity Assessment of Traditional Herbal Medicines. Nat Prod Commun, 11(11):1763–73.




DOI: http://dx.doi.org/10.18063/ghl.v4i1.280

Refbacks

  • There are currently no refbacks.


Copyright (c) 2022 Mohammad Khalid Parvez

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Recent Articles | About Journal | For Author | Fees | About Whioce

Copyright © Whioce Publishing Pte Ltd. All Rights Reserved.