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Liver Diseases and Adverse Reactions Induced by Medicinal Herbs and Herb-Drug Interactions
Abstract
Integrative medicine encompasses several modalities of complementary and alternative medicine, of which the most relevant is the herbal medicine. Herbal formulations contain multiple pharmacologically active phytochemicals with isolated active compounds usually can achieve better therapeutic performance. In general, herbal medicines are believed to be more effective and safer than prescription drugs. Prescription drugs are approved and licensed only after well regulated clinical trials have been carried out, but a majority of marketed herbal products remain non-regulated without evidence of efficacy and safety. In this article, we review the potential risk of liver diseases or other organ toxicity related to herbs or the combined use of herb and drug. This article also discusses certain medicinal herbs as well as hepatotoxicy and adverse reactions induced by herb-drug interactions in liver disease patients.
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Kennedy J, 2005, Herb and Supplement Use in the US Adult Population. Clin Ther, 27(11):1847–58. DOI: 10.1016/j. clinthera.2005.11.004
Song PP, Gao JJ, Kokudo N, et al., 2011. Standardization of Traditional Chinese Medicine and Evaluation of Evidence from its Clinical Practice. Drug Discov Ther, 5(6):261–5. DOI: 10.5582/ddt.2011.v5.6.261
Hudson A, Lopez E, Almalki AJ, et al., 2018. A Review of the Toxicity of Compounds Found in Herbal Dietary Supplements. Planta Med, 84:613–26. DOI: 10.1055/a 0605-3786
Charen E, Harbord N, 2020. Toxicity of Herbs, Vitamins, and Supplements. Adv Chronic Kidney Dis, 27:67–71. DOI: 10.1053/j.ackd.2019.08.003
Al-Dosari MS, Parvez MK, 2016. Genetic Polymorphisms of Drug Eliminating Enzymes and Transporters. Biomed Gen Genom, 1:44–50. DOI: 10.15761/BGG.1000109
Chen XW, Sneed KB, Pan SY, et al., 2012. Herb Drug Interactions and Mechanistic and Clinical Considerations. Curr Drug Metab, 13:640–51. DOI: 10.2174/1389200211209050640
Bunchorntavakul C, Reddy KR, 2013, Review article: Herbal and dietary supplement hepatotoxicity. Aliment Pharmacol Ther, 37:3–17. DOI: 10.1111/apt.12109
Teschke R, Wolff A, Frenzel C, et al., 2014, Drug and Herb Induced Liver Injury: Council for International Organizations of Medical Sciences scale for Causality Assessment. World J Hepatol, 6:17–32. DOI: 10.4254/wjh. v6.i1.17
Kim TY, Kim D, 2013, Acute-on-chronic Liver Failure. Clin Mol Hepatol, 19:349–59. DOI: 10.3350/cmh.2013.19.4.349
Gunawan B, Kaplowitz N, 2004, Clinical Perspectives on Xenobiotic Induced Hepatoxicity. Drug Metab Rev, 36:301–12. DOI: 10.1081/dmr-120034148
Pittler MH, Ernst E, 2003, Systematic Review: Hepatotoxic Events Associated with Herbal Medicinal Products. Aliment Pharmacol Ther, 18:451–71. DOI: 10.1046/j.1365- 2036.2003.01689.x
Schiano TD, 2003, Hepatotoxicity and Complementary and Alternative Medicines. Clin Liver Dis, 7(2):453–73. DOI: 10.1016/s1089-3261(03)00030-8
Stedman C, 2002, Herbal Hepatotoxicity. Semin Liver Dis, 22(2): 195–206. DOI: 10.1055/s-2002-30104
Teschke R, Bahre R, 2009. Severe Hepatotoxicity by Indian Ayurvedic Herbal Products: A Structured Causality Assessment. Ann Hepatol, 8(3):258–66.
Jorge OA, Jorge AD, 2005. Hepatotoxicity Associated with the Ingestion of Centella asiatica. Rev Esp Enferm Dig, 97:115–24. DOI: 10.4321/s1130-01082005000200006
Fleig WW, Morgan MY, Holzer MA, 1997. European Multicenter Study Group. The ayurvedic drug Liv.52 in patients with alcoholic cirrhosis. Results of a prospective, randomized, double-blind, placebo-controlled clinical trial. J Hepatol, 126:127.
Izzo AA, Ernst E, 2001. Interactions between Herbal Medicines and Prescribed Drugs: A Systematic Review. Drugs, 61:2163–75. DOI: 10.2165/00003495-200161150- 00002
Woo CS, Lau JS, El-Nezami H, 2012, Herbal Medicine: Toxicity and Recent Trends in Assessing their Potential Toxic Effects. In: Advances in Botanical Research, Cambridge, Massachusetts: Academic Press, pp. 365–84.
Modi AA, Wright EC, Leonard BS, 2007. Complementary and Alternative Medicine for the Treatment of Hepatitis B and C: A Review. Antiviral Ther, 12(3):285–95.
Parvez MK, Al-Dosari MS, Arbab AH, 2021, An update on natural or herbal drugs against hepatitis B virus. In: Hepatitis B: Diagnosis, Prevention and Treatment. New York: Nova Science Publishers, Inc.
Yuen MF, Tam S, Fung J, Wong DK, Wong BC, Lai CL, 2006. Traditional Chinese Medicine Causing Hepatotoxicity in Patients with Chronic Hepatitis B Infection: A 1-year Prospective Study. Aliment Pharmacol Ther, 24(8):1179–86. DOI: 10.1111/j.1365-2036.2006.03111.x
Lee CH, Wang JD, Chen PC, 2011. Risk of Liver Injury Associated with Chinese Herbal Products Containing Radix Bupleuri in 639,779 Patients with Hepatitis B Virus Infection. PLoS One, 6(1):e16064. DOI: 10.1371/journal. pone.0016064
Estes JD, Stolpman D, Olyaei A, et al., 2003. High Prevalence of Potentially Hepatotoxic Herbal Supplement Use in Patients with Fulminant Hepatic Failure. Arch Surg, 138(8):852–8. DOI: 10.1001/archsurg.138.8.852
Choi HA, Kim MR, Park KA, et al., 2012. Interaction of over-the-Counter Drugs with Curcumin: Influence on Stability and Bioactivities in Intestinal Cells. J Agric Food Chem, 60(42):10578–84. DOI: 10.1021/jf303534e
Choi JG, Eom SM, Kim J, et al., 2016. A comprehensive review of recent studies on herb-drug interaction: A focus on pharmacodynamic interaction. J Altern Complement Med, 22:262–79. DOI: 10.1089/acm.2015.0235
Reeta KH, Mehla J, Pahuja M, et al., 2011. Pharmacokinetic and Pharmacodynamic Interactions of Valproate, Phenytoin, Phenobarbitone and Carbamazepine with Curcumin in Experimental Models of Epilepsy in Rats. Pharmacol Biochem Behav, 99:399–407. DOI: 10.1016/j. pbb.2011.05.011
Zhou S, Gao Y, Jiang W, et al., 2003, Interactions of Herbs with Cytochrome P450. Drug Metab Rev, 35:35–98. DOI: 10.1081/dmr-120018248
Food and Drug Administration, 2006, Guidance for Industry on Complementary and Alternative Medicine Products and Their Regulation by the Food and Drug Administration. Draft Guidance, pp. 1–17.
Aydιn A, Aktay G, Yesilada E, 2016, A Guidance Manual for the Toxicity Assessment of Traditional Herbal Medicines. Nat Prod Commun, 11(11):1763–73.
DOI: http://dx.doi.org/10.18063/ghl.v4i1.280
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