Metastatic Choroidal Melanoma and Liver Metastasis: A Case Report

VIEWS - 180 (Abstract) 54 (PDF)
Sabhita Shabir Shaikh, Raheela Khalid

Abstract


Metastatic melanoma to liver is rare in adults. Melanoma can arise from the skin and uveal tract of eyes and metastasizes to other organs, including liver. A middle-aged man who had right eye enucleation 5 years ago due to choroidal melanoma was presented with nonspecific abdominal symptoms for a 6-month duration. He had mild tenderness in the right hypochondriac region. An abdominal ultrasound examination showed two hypoechoic lesions that are suggestive of metastatic deposits. Triphasic computed tomography scan of the abdomen showed heterogeneously enhancing lesion that is indicative of hepatoma. Magnetic resonance imaging revealed T2 iso- to hyperintense lesion, giving differential diagnoses of focal nodular hyperplasia, hepatic adenoma, and fibrolamellar carcinoma. Immunohistochemistry results showed that the tumor cells derived from liver biopsy contain melanin as they are positive for both S-100 and MART-1, indicating that the tumor is melanoma. The histopathological examination should be performed on tumor cells from patients who have an increased risk for metastatic melanoma in the liver due to choroidal melanoma.

Keywords


Choroidal melanoma, Liver metastasis

Full Text:

Download PDF

References


Du F, Yang M, Fang J, et al., 2015, Primary Hepatic Malignant Melanoma: A Case Report. Int J Clin Exp Pathol, (2):2199–201.

Ornellas LC, Lanzoni VP, Toledo CF, 2000, Malignant Melanoma with Liver and Spleen Metastases: Case Report. Sao Paulo Med J, 118:53–6. DOI: 1590/s1516- 31802000000200006.

Ao W, Wang J, Mao G, et al., 2019, Primary Hepatic Melanoma: A Case Report of Computed Tomography and Magnetic Resonance Imaging Findings. Medicine, 98(25):e16165. DOI: 10.1097/md.0000000000016165,

Karde SR, Bhand PR, Ramesh N, et al,. 2016, Metastatic Melanoma after 23 Years of Primary Ocular Melanoma. BMJ Case Rep, 2016:bcr2016217503. DOI: 10.1136/bcr- 2016-217503.

Kaliki S, Shields CL, 2017, Uveal Melanoma: Relatively Rare but Deadly Cancer. Eye, 31(2):241–57. DOI: 10.1038/ eye.2016.275.

Zbytek B, Carlson JA, Granese J, et al., 2008, Current Concepts of Metastasis in Melanoma. Expert Rev Dermatol, 3(5):569–85.

Carr S, Smith C, Wernberg J, 2020, Epidemiology and Risk Factors of Melanoma. Surg Clin North Am, 100(1):1–12.

Chattopadhyay C, Kim DW, Gombos DS, et al., 2016, Uveal Melanoma: From Diagnosis to Treatment and the Science in between. Cancer, 122(15):2299–312.

Mouchli MA, Kerr SE, Roberts L, 2018, An Enlarging Metastatic Calcified Liver Lesion of an Occult Melanoma. Case Rep Oncol, 11(2):388–91. DOI: 10.1159/000489555.

Bostanci O, Kartal K, Battal M, 2014, Liver Metastases of Unknown Primary: Malignant Melanoma. Case Rep Hepatol, 2014:131708. DOI: 10.1155/2014/131708.

Aisner DL, Maker A, Rosenberg SA, et al, 2005, Loss of S100 Antigenicity in Metastatic Melanoma. Hum Pathol, 36(9):1016–9. DOI: 10.1016/j.humpath.2005.07.010.

Cherpelis BS, Moore R, Ladd S, et al., 2009, Comparison of MART-1 Frozen Sections to Permanent Sections Using a Rapid 19-Minute Protocol. Dermatol Surg 35(2):207–13. DOI: 10.1111/j.1524-4725.2008.34411.x.

Karlen AI, Clark JJ, Wong LL, 2012, Two Cases of Partial Hepatectomy for Malignant Melanoma. Hawaii J Med Public Health, 71(4):92–6.

Vallianou N, Kouvidou C, Geladari E, et al., 2016, Rare Delayed Metastasis of Uveal Melanoma Presenting as Fulminant Liver Failure. J Clin Gastroenterol Treat, 2:37. DOI: 10.23937/2469-584x/1510037.

Carvajal RD, Schwartz GK, Tezel T, et al., 2017, Metastatic Disease from Uveal Melanoma: Treatment Options and Future Prospects. Br J Ophthalmol, 101(1):38–44. DOI: 10.1136/bjophthalmol-2016-309034.

Bostanci O, Kartal K, 2014, Liver Metastases of Unknown Primary: Malignant Melanoma. Case Rep Hepatol, 2014:131708.




DOI: http://dx.doi.org/10.18063/ghl.v2i1.252

Refbacks

  • There are currently no refbacks.


Copyright (c) 2020 Shaikh and Khalid

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Recent Articles | About Journal | For Author | Fees | About Whioce

Copyright © Whioce Publishing Pte Ltd. All Rights Reserved.